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Can vaccination produce protective antibodies in people who fail to develop protective antibodies after recovery from COVID-19 infection

Humoral response to SARS-CoV-2 vaccination after failure to develop adequate humoral immunity post natural exposure to the virus

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/04/032572
Enrollment
35
Registered
2021-04-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

None listed

Sponsors

Rajiv Gandhi Cancer Institute and Research Centre
Lead Sponsor
Dr Rajiv Chawla
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: HCW Employed at RGCI Either sex 18-70 years History of positive RT-PCR test for SARS-CoV-2 Either undetectable ( Vaccinated

Exclusion criteria

Exclusion criteria: Non Health Care Worker Not an employee of Rajiv Gandhi Cancer Institute Not vaccinated against COVID-19

Design outcomes

Primary

MeasureTime frame
IgG antibody titreTimepoint: 7-14 days post first dose of vaccination 28 days post second dose of vaccination—

Secondary

MeasureTime frame
FeverTimepoint: Post first dose of vaccination Post second dose of vaccination;MyalgiaTimepoint: Post first dose of vaccination Post second dose of vaccination;HeadacheTimepoint: Post first dose of vaccination Post second dose of vaccination;Pain at injection siteTimepoint: Post first dose of vaccination Post second dose of vaccination;RashesTimepoint: Post first dose of vaccination Post second dose of vaccination;MalaiseTimepoint: Post first dose of vaccination Post second dose of vaccination;Any other symptomTimepoint: Post first dose of vaccination Post second dose of vaccination;MedicationTimepoint: Post first dose of vaccination Post second dose of vaccination;ChillsTimepoint: Post first dose of vaccination Post second dose of vaccination—

Countries

India

Contacts

Public ContactShagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre

drshagun_2010@rediffmail.com9891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026