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The role of serum microRNAs and inflammatory mediators in intervertebral disc degeneration and their value as biomarkers

The role of serum microRNAs and inflammatory mediators in intervertebral disc degeneration (IDD) and their value as biomarkers for early detection of intervertebral disk degeneration (IDD)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/04/032570
Enrollment
168
Registered
2021-04-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M472- Other spondylosis with radiculopathy

Interventions

None listed

Sponsors

Yenepoya University Deemed to be
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients with low backache and who have undergone MRI for the evaluation of backache, which confirms the presence of disc degeneration of the lumbar spine.

Exclusion criteria

Exclusion criteria: Patients with a history of previous trauma or infections to the spine. Diabetes mellitus, patients with inflammatory arthritis. Patients who have undergone previous surgery. Patients who have major deformities like scoliosis and kyphosis.

Design outcomes

Primary

MeasureTime frame
1. List of miRNAs and serum proteins from disc material and blood. 2. Correlation of these miRNA and serum proteins between different age groups, and different grades of disc degeneration.Timepoint: 0 (Baseline)—

Secondary

MeasureTime frame
Validation of miRNA and serum biomarkers using literature.Timepoint: 0-2 years—

Countries

India

Contacts

Public ContactDr Prashant Kumar Modi

Yenepoya Research centre Mangalore

prashantmodi@yenepoya.edu.in9873662911

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026