Evaluation of opioid free anaesthetic technique with lignocaine and magnesium sulphate infusion for laparoscopic cholecystectomy

Efficacy of Lignocaine Hydrochloride and Magnesium Sulphate versus Fentanyl Anaesthesia in Laparoscopic Cholecystectomy: A Randomised Controlled Study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/04/032520

Enrollment

150

Registered

2021-04-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lignocaine Hydrochloride and Magnesium Sulphate VS Fentanyl: Group B 1. Intravenous lignocaine bolus before induction of anaesthesia followed by lignocaine infusion intraoperatively 2.

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Grade I, II 2. Laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: Inability to obtain informed consent. 1. Patients on chronic use of opioid or beta blockers. 2. Known case of severe mental impairment. 3. Known allergy to study medication. 4. Inability to comprehend pain assessment preoperatively. 5. History of alcohol, drug abuse. 6. Received opioid medication within 24 hours before operation. 7. Pregnant or breast-feeding females. 8. Patients with cardiac, hepatic and renal insufficiency. 9. Patients with difficult airway.

Design outcomes

Primary

Measure	Time frame
Primary outcome measure: Postoperative analgesic consumption till 24hrs/ discharge or patient need. Secondary outcome measure: 1. Intraoperative a. Haemodynamic stability 2. Postoperative: a. Pain scores at time points. b. Nausea and vomiting (PONV) c. Recovery time from general anaesthesia.Timepoint: Primary outcome measure: Postoperative analgesic consumption till 24hrs/ discharge or patient need. Secondary outcome measure: 1. Intraoperative a. Haemodynamic stability 2. Postoperative: a. Pain scores at time points. b. Nausea and vomiting (PONV) c. Recovery time from general anaesthesia.	—

Measure

Time frame

Primary outcome measure: Postoperative analgesic consumption till 24hrs/ discharge or patient need. Secondary outcome measure: 1. Intraoperative a. Haemodynamic stability 2. Postoperative: a. Pain scores at time points. b. Nausea and vomiting (PONV) c. Recovery time from general anaesthesia.Timepoint: Primary outcome measure: Postoperative analgesic consumption till 24hrs/ discharge or patient need. Secondary outcome measure: 1. Intraoperative a. Haemodynamic stability 2. Postoperative: a. Pain scores at time points. b. Nausea and vomiting (PONV) c. Recovery time from general anaesthesia.

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Secondary

Measure	Time frame
In patients undergoing laparoscopic cholecystectomy under general anaesthesia, to compare following outcomes with use of fentanyl versus lignocaine and magnesium sulphate: 1. Intraoperative haemodynamics stability. 2. Incidence of postoperative nausea and vomiting. 3. Recovery time from general anaesthesia. Timepoint: Intraoperative to postoperative till discharge	—

Countries

India

Contacts

Public ContactDr Anil Kumar Jain

Sir Ganga Ram Hospital

akfeb55jain@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026