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To see how similar are the results of Truenat and CBNAAT (two tests used to diagnose Tuberculosis of the brain) in children.

Evaluation of Truenat and CBNAAT for detection of Tubercular Meningitis in children and adolescents.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/04/032509
Enrollment
70
Registered
2021-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A170- Tuberculous meningitis Health Condition 2: A170- Tuberculous meningitis

Interventions

None listed

Sponsors

Department of Pediatrics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Suspected case of Tubercular Meningitis13 as evidenced by: Fever >5days, weight loss, anorexia along with neurological signs and symptoms (headache, vomiting, irritability, lethargy, seizures, confusion, coma, neck stiffness, cranial nerve palsy, hemiparesis) and CSF showing presence of 10-500 WBC/mm3, lymphocytes >50% and CSF/Plasma glucose WBC in blood And/or imaging with evidence of basal meningeal enhancement, hydrocephalous or cerebral infarct or tuberculoma

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

MeasureTime frame
Cohens kappa coefficient to find out the degree of reliability between MTB detection by Truenat and CBNAAT in CSF samples.Timepoint: 1 year—

Secondary

MeasureTime frame
Difference in proportions of positivity status of CBNAAT and Truenat with respect to severity of disease. Timepoint: 1 year—

Countries

India

Contacts

Public ContactDr Stuti Sharma

Maulana Azad Medical College and Associated Lok Nayak Hospital

doctoranuragagarwal@gmail.com9810409625

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026