Comparing the two different doses of nasal spray to reduce the hemodynamic changes that occur during carbon dioxide insufflation during key hole surgeries

TO ASSESS THE EFFECT OF TWO DIFFERENT DOSES OF INTRANASAL NITROGLYCERINE SPRAY ON ATTENUATION OF HEMODYNAMIC STRESS RESPONSE DUE TO PNEUMOPERITONEUM IN LAPAROSCOPIC SURGERIES.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/03/032461

Enrollment

Registered

2021-03-31

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: R198- Other specified symptoms and signsinvolving the digestive system and abdomen

Interventions

Intervention1: N8: N8 will recieve dose of 800 mcg of intranasal nitroglycerine Control Intervention1: N4: N4 will receive dose of 400 mcg of intranasal nitroglycerine

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are willing to give informed consent Patients of age 18-60 years. ASA grade 1 & 2 Patients with BMI 19-25 kg/m2 Patients undergoing elective laparoscopic surgeries

Exclusion criteria

Exclusion criteria: Patient refusal. Patients with history of anemia Patients with hypotension ( SBP Patients who are allergic to nitrates Patient on phosphodiesterase inhibitors, antihypertensives, sympathomimetics

Design outcomes

Primary

Measure	Time frame
Hemodynamic stress responseTimepoint: After premedication, before and after induction, intubation, after drug till end of surgery and post operatively	—

Secondary

Measure	Time frame
Side effects of the study drugTimepoint: Intra and post operatively	—

Countries

India

Contacts

Public ContactDr Nethra SS

Bangalore Medical College and Research Institute

swathisaggi@gmail.com9972454989

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026