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Discovery of neo-antigen peptide in the common primary brain tumours

Development of a Multi-omics based Neoantigen Discovery Platform to generate Personalized Vaccines for Gliomas

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/03/032438
Enrollment
75
Registered
2021-03-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified

Interventions

Intervention1: Not Applicable: Not Applicable Control Intervention1: Not Applicable: Not Applicable

Sponsors

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Morphology and histology confirmed diffuse gliomas of different WHO grades of II, III and IV, where sufficient tissue will be available for all components of the studies. 2. Karnofsky Performance Status should be more than or equal to 60. 3. Patients should be able to provide written informed consent for the collection and usage of the clinical samples for research purpose. 4. Both primary and recurrent tumors can be collected for research purpose.

Exclusion criteria

Exclusion criteria: 1. Patients, who are not able to provide written consent, should be excluded from the study. 2. Mixed CNS tumors or patients suffering from other cancers should be excluded. 3. Patients suffering from associated viral, bacterial, protozoan and fungal diseases should be excluded. 4. Patients with another neurological disorders/ organ failure should be excluded. Patients undergoing treatment for diseases other than specified CNS tumors should be excluded.

Design outcomes

Primary

MeasureTime frame
Not applicable; this is a biology exploratory studyTimepoint: Outcome will be assessed after the study completion

Secondary

MeasureTime frame
Not applicableTimepoint: Not applicable

Countries

India

Contacts

Public ContactDr Epari Sridhar

Tata Memorial Hospital

sridhep@gmail.com02224177000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026