Health Condition 1: J99- Respiratory disorders in diseasesclassified elsewhere
Conditions
Interventions
Intervention1: transpulmonary presssure measurement: While undergoing treatment, the subjects will be supine, with the head of the bed elevated to 30 degrees. Airway pressure, tidal volumes and other
Sponsors
self
Eligibility
Inclusion criteria
Inclusion criteria: Patients will be included in the study if they have moderate-to-severe ARDS according to the American-European Consensus Conference definitions. Duration of ARDS 36 hours or less from meeting final Berlin criterion Age more than 18 years.
Exclusion criteria
Exclusion criteria: Received mechanical ventilation more than 96â??h. Recently treated for bleeding varices, stricture, haematemesis, esophageal trauma, recent esophageal surgery or other contraindication for nasogastric tube placement. History of lung or liver transplantation. Severe chronic liver disease (Child-Pugh Score >=12). Patients not committed to full support. Inability to get informed consent from the patient or surrogate. Use of rescue therapies prior to enrolment (including nitric oxide, ECMO, prone positioning) Evidence of active air leak from the lung (including bronchopleural fistula, pneumothorax, pneumomediastinum or air leak from existing chest tube).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in PaO2 /FiO2 ratio Improvement in static compliance VILI like spontaneous pneumothorax Improvement in CO2 exchangeTimepoint: outcomes measured at baseline, at 6 and 12 hours respectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| noneTimepoint: none | — |
Countries
India
Contacts
Public ContactDr M Ravi krishna
dayanand medical college and hospital
Outcome results
None listed