Comparison of ketamine and normal saline giving before surgery for pain control in tonsil removal surgery patients

COMPARISON OF PREEMPTIVE NEBULISED KETAMINE,INTRAVENOUS KETAMINE AND PLACEBO FOR PAIN CONTROL AFTER TONSILLECTOMY IN CHILDREN:A DOUBLE BLINDED THREE ARM RANDOMISED CONTROLLED TRIAL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/03/032391

Enrollment

Registered

2021-03-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J039- Acute tonsillitis, unspecified

Interventions

Intervention1: pre emptive iv ketamine: Group C will receive saline nebulisation 30 min prior to surgery and intravenous ketamine(0.5mg/kg) after induction Control Intervention1: pre emptive neb

Eligibility

Inclusion criteria

Inclusion criteria: 1 ASA physical status I and II 2 Age between 5 to 12 years. 3 Patients undergoing elective tonsillectomy

Exclusion criteria

Exclusion criteria: 1. Guardiansâ?? refusal to give consent. 2. Allergy to study drug. 3 Increased intracranial pressure or intraocular pressure 4 Patient with known history of porphyria 5 Patient with cardiac ,respiratory ,neuropsychiatric disorder

Design outcomes

Primary

Measure	Time frame
Based on our study, we are expecting that, Compared to placebo ,pre-emptive intravenous ketamine and pre-emptive nebulized ketamine may significantly prolong the time to first request for rescue analgesia and reduce total 24 hour consumption of rescue analgesics without significant adverse events after tonsillectomyTimepoint: Based on our study, we are expecting that, Compared to placebo ,pre-emptive intravenous ketamine and pre-emptive nebulized ketamine may significantly prolong the time to first request for rescue analgesia and reduce total 24 hour consumption of rescue analgesics without significant adverse events after tonsillectomy	—

Measure

Time frame

Based on our study, we are expecting that, Compared to placebo ,pre-emptive intravenous ketamine and pre-emptive nebulized ketamine may significantly prolong the time to first request for rescue analgesia and reduce total 24 hour consumption of rescue analgesics without significant adverse events after tonsillectomyTimepoint: Based on our study, we are expecting that, Compared to placebo ,pre-emptive intravenous ketamine and pre-emptive nebulized ketamine may significantly prolong the time to first request for rescue analgesia and reduce total 24 hour consumption of rescue analgesics without significant adverse events after tonsillectomy

—

Secondary

Measure	Time frame
Based on our study, we are expecting that, Compared to placebo ,pre-emptive intravenous ketamine and pre-emptive nebulized ketamine may significantly prolong the time to first request for rescue analgesia and reduce total 24 hour consumption of rescue analgesics without significant adverse events after tonsillectomyTimepoint: 1.5 yrs of study from 30th march to 30th september 2022	—

Countries

India

Contacts

Public ContactDr Vaishali malik

S. NIJALINGAPPA MEDICAL COLLEGE AND HANAGAL SHRI KUMARESHWAR HOSPITAL AND RESEARCH CENTRE

drchhayajoshi1@gmail.com9743320105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026