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Comparative study of 2 different blood pressure targets while treating low blood pressure due to severe infection in children

Higher Versus Lower Mean Arterial Blood Pressure Targets for Vasopressor Therapy in Hypotensive septic Shock in Pediatric lntensive Care Unit

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032377
Enrollment
142
Registered
2021-03-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I959- Hypotension, unspecified

Interventions

Intervention1: Target Mean Blood Pressure at 5th centile for age: Vasoactive agents such as dopamine, adrenaline or noradrenaline will be used to achieve this target Control Intervention1: Target Mean

Sponsors

Surya Mother and Child Superspeciality Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients presenting to PICU in the age group of 1 month to 16 years with septic shock refractory to fluid boluses and needing vasopressors would be enrolled. Children will be enrolled as soon as they are started on vasopressors.

Exclusion criteria

Exclusion criteria: Patients with traumatic brain injury will be excluded. Patients referred from other centre who has received vasopressors for more than 24 hours will also excluded. Children presenting with haemorrhagic shock will also be omitted from the study.

Design outcomes

Primary

MeasureTime frame
Primary outcome is death from any cause by 28 days of inclusion.Timepoint: Primary outcome is death from any cause by 28 days of inclusion.

Secondary

MeasureTime frame
Length of stay in ICU. Length of stay in the hospital. Occurrence of vasopressor-induced adverse events namely extravasation, limb /digit necrosis, arrhythmias, bowel ischemia, feed intolerance, venous thromboembolic events.Timepoint: 28 days of inclusion in study

Countries

India

Contacts

Public ContactDr Amita Kaul

Surya Mother and Child Superspeciality hospital

amitakaul@hotmail.com9370694634

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026