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A study to compare the effectiveness and pain associated with the use of normal irrigation and new irrigation HEBP in root canal treatment of adult permanent teeth

Comparative evaluation of the depth of penetration and post operative pain associated with the use of continuous chelation using HEBP and standard irrigation protocol in the endodontic treatment of adult permanent non vital teeth- A randomized controlled trial - HEBP

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032370
Enrollment
46
Registered
2021-03-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Hydroxyethylidene-1, 1-Bisphosphonate (HEBP): 9% HEBP with 3%sodium hypochloride as final root canal irrigant, 1ml per canal Control Intervention1: sodium hypochloride followed by ethyl

Sponsors

Dr Janhvi Samir Parekh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologist (ASA) category I and category II adult patients aged between 18-45 years. ii) Adult permanent asymptomatic non vital teeth requiring endodontic treatment iii) Teeth whose non vitality is confirmed by Electric pulp tester (EPT) and thermal sensitivity testing. iv) Feasibility of isolating the tooth with rubber dam with or without endodontic build up. v) Vertucci type I and type IV root canal anatomy shall be taken for this study vi) Subjects with the ability to understand the consent forms and the pain record scales.

Exclusion criteria

Exclusion criteria: Non vital tooth with periapical lesion ii) Patients with preoperative pain (pain ranging for 1-10 on a numerical rating scale) iii) Patients who have taken Non steroidal anti-inflammatory drugs (NSAID) or any other analgesic for pain within last 4-8 hours iv) Teeth with calcified root canals v) Periodontally compromised teeth vi) Teeth with complex root canal anatomy vii) Patient not willing to give consent for the study viii) Violation of the apical constriction during cleaning and shaping ix) Patients with known allergy to the materials used in the study x) Patient not reporting for follow up

Design outcomes

Primary

MeasureTime frame
post operative pain and depth of penetrationTimepoint: 6 hours

Secondary

MeasureTime frame
post operative pain and depth of penetrationTimepoint: 24 hours

Countries

India

Contacts

Public ContactDr Janhvi Samir Parekh

Dr. G.D Pol Foundations, Yerela Medical Trust Dental College and Hospital

drmrunalvaidya@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026