Health Condition 1: C159- Malignant neoplasm of esophagus, unspecified
Conditions
Interventions
None listed
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed non-recurrent non-metastatic squamous cell carcinoma or adenocarcinoma of esophagus or gastroesophageal junction (GEJ). 2. Patients must be considered as having inoperable/unresectable tumor, considered to be unfit for surgery and/or are unwilling for surgery. 3. ECOG performance status less than or equal to 2. 4. Adequate baseline bone marrow, liver and renal functions as determined by routine standard-of-care tests. 5. Patients being treated using VMAT technique. 6. Willingness to participate in the study and provides a voluntary informed consent.
Exclusion criteria
Exclusion criteria: 1. Metastatic disease at presentation. 2. History of prior mediastinal/thoracic malignancy or condition that warranted irradiation or chemotherapy. 3. Patients with tracheoesophageal fistula/bronchoesophageal fistula. 4. Patients with active second malignancy. 5. Uncontrolled co-morbidities that would hamper the patientsâ?? adherence to treatment. 6. Known contraindications to use of concurrent chemotherapy (E.g.: impaired renal/hematological function, known hypersensitivity, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the local control rates and disease-free survival (DFS) in esophageal cancer following definitive chemoradiotherapy by VMAT technique.Timepoint: At completion of treatment course, 1 month, 3 months and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare target volume coverage and normal tissue exposure dosimetrically between VMAT and 3D-CRT technique.Timepoint: At 6 months.;To correlate between dose exposure to organs-at-risk (OARs) and acute toxicity.Timepoint: At 6 months.;To correlate between radiation dose used and disease outcomes.Timepoint: At 1 month, 3 months and 6 months.;To report on acute and long-term treatment toxicities.Timepoint: At presentation of primary event. | — |
Countries
India
Contacts
Public ContactDr Krishna Sharan
Kasturba Medical College and Hospital, Manipal
Outcome results
None listed