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An observational study about the clinical profile of Hemophagocytic Lymphohistiocytosis(a disease in which own immune cells eat up blood cells resulting in fall of blood cells) in children less than 12 years and about markers that decide good and bad prognosis of the disease.

Clinical, Epidemiological and Hematological profile of Hemophagocytic Lymphohistiocytosis in Children less than 12 years and Rate of decline of Ferritin as a prognostic marker for disease outcome.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/03/032323
Enrollment
30
Registered
2021-03-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D761- Hemophagocytic lymphohistiocytosis

Interventions

None listed

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children less than 12yrs fulfilling criteria of Hemophagocytic lymphohistiocytosis. 1.A molecular diagnosis consistent with HLH (e.g., PRF mutations, SAP mutations) or 2. Presence of 5 of the following 8 symptoms, signs, or laboratory abnormalities: a. Fever b. Splenomegaly c. Cytopenia (affecting >=2 cell lineages; hemoglobin d. Hypertriglyceridemia (>=265 mg/dL) and/or hypofibrinogenemia ( e. Hemophagocytosis in the bone marrow, spleen, or lymph nodes without evidence of malignancy f. Low or absent natural killer cell cytotoxicity g. Hyperferritinemia (>=500 ng/mL) h. Elevated soluble CD25 (interleukin-2Rα chain; >=2,400 U/mL)

Exclusion criteria

Exclusion criteria: Macrophage Activation Syndrome (MAS) associated with Autoimmune disease 1.Systemic-onset juvenile idiopathic arthritis 2.Systemic lupus erythematosus 3.Enthesitis-related arthritis 4.Inflammatory bowel disease

Design outcomes

Primary

MeasureTime frame
Clinical, Epidemiological and Hematological profile of Hemophagocytic lymphohistiocytosis in children less than 12 years in a tertiary health centerTimepoint: Assessment of Participants from the time of admission for the entire period of hospital stay—

Secondary

MeasureTime frame
Rate of fall of ferritin as a prognostic markerTimepoint: Every 5 days once S.Ferritin will be repeated until normalises—

Countries

India

Contacts

Public ContactProf Dr S Lakshmi

Institute of Child Health and Hospital for Children, Madras Medical College

lakshmivel67@yahoo.co.in9840786852

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026