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The Effect of Topical Application of 5-fluorouracil during Functional Endoscopic Sinus Surgery(FESS) in the prevention of nasal adhesions post-surgery.

The Effect of Topical 5-Fluorouracil Postâ??Functional Endoscopic Sinus Surgery.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032286
Enrollment
68
Registered
2021-03-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A488- Other specified bacterial diseases

Interventions

Intervention1: 5 FLUOROURACIL: Route : Topical Dose : Upon completion of surgery, application of topical 5-FU will be done unilaterally. 1 mL of 5-FU (1000mg/20mL) will be diluted with 9ml of 0.9% s

Sponsors

Dr Lekhaa M
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients of either age between 18 to 60 years 2 Diagnosis of bilateral chronic sinusitis who have had no relief with maximum medical therapy 3 Similar Lund Makay Scoring on both sides

Exclusion criteria

Exclusion criteria: Revision Endoscopic Sinus surgery Uncontrolled systemic illness Known allergy to 5 FU Pregnancy and lactation Pre-existing septal perforation or adhesion

Design outcomes

Primary

MeasureTime frame
Formation of adhesions post-operativelyTimepoint: At 2nd 4th and 12th week postoperatively—

Secondary

MeasureTime frame
Reduction in formation of nasal crusting postoperativelyTimepoint: At 2nd 4th and 12th week postoperatively—

Countries

India

Contacts

Public ContactDrLekhaa M

Sri Ramachandra Institute of Higher Education and Research.

somu_l1496@yahoo.com9600000644

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026