Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: intravenous lignocaine: Patients will receive 1.5 mg.kg-1 IV lignocaine 2% preservative free in 5cc syringe over 5 minutes prior to induction, followed by infusion of 1.5 mg.kg-1.hr-1 I
Sponsors
Government medical college and hospital Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.ASA (American Society of Anesthesiologists) grade I-II patients 2.Patients scheduled to undergo restoration of bowel continuity
Exclusion criteria
Exclusion criteria: 1. Cardiac conduction abnormalities and congestive heart failure 2. Renal or hepatic impairment 3. Neurological disorders 4. Pregnant and lactating women 5. Patients not able to understand VAS 6. History of substance abuse 7. Contraindications to study drugs: lignocaine, paracetamol ,tramadol and diclofenac 8. Chronic pain conditions, neurodegenerative or autoimmune disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum lactate dehydrogenase (LDH) and lactate levelsTimepoint: Baseline before surgery, before extubation, after 6h ,24h | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Visual analogue scale at rest and on movement 2. Time to rescue analgesia and total rescue analgesia 3. Arterial blood gas(ABG) analysis 4. Haemodynamics Timepoint: 1. VAS score: baseline, post extubation, 1h in postoperative care unit (PACU), at 6h, 12 h and 24 h. 2. Time to first rescue and total analgesia: in PACU and in postoperative period upto 24 h. 3. Baseline before surgery, before extubation, after 6h ,24h 4.Haemodynamics (PR, BP,RR): baseline, at time of induction, after intubation, every 5 minutes during surgery, at time of extubation, every 5 minutes for 15 min, every 15 minutes upto 1 h in PACU, then in ward at 6 h, 12 h and 24 h. | — |
Countries
India
Contacts
Public ContactDr Kushagrita Singh
Government medical college and hospital, sector 32, Chandigarh
Outcome results
None listed