Comparison of Intracanal Medicaments in Incidence of Post-Operative Endodontic Pain

Comparative Evaluation of Post-Operative Endodontic Pain Using Various Intracanal Medicaments After Instrumentation with Rotary Single-File System-In Vivo Study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/03/032269

Enrollment

Registered

2021-03-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K044- Acute apical periodontitis of pulpal origin Health Condition 3: K045- Chronic apical periodontitis

Interventions

Intervention1: 0.9% Normal Saline: Fresh solution, 5ml inside the canal Control Intervention1: Calcium hydroxide and 2% Chlorhexidine gel : Gels and sloutions will be prepared in the above concentrati

Eligibility

Inclusion criteria

Inclusion criteria: 1. Vital and non-vital Mandibular 1st and 2nd molars 2. Presence of occlusal caries 3. Symptomatic patients with moderate pain 4. Radiographically verified Apical Periodontitis with widening of the Periodontol Ligament Space 5. Periapical lesion less than 2mm 6. Fully formed root apices 7. Age 25-45 yrs 8. Systemically Healthy Patients

Exclusion criteria

Exclusion criteria: 1. Large periapical( >2mm) lesion seen radiographically 2. Roots with apical patency equal to or more than #25 3. Teeth with Proximal Caries 4. Pulpal involvements with any other tooth from that side 5. Roots showing internal and external resorption 6. Cracked roots 7. Calcified root 8. Root Curvatures >20o. 9. Developmental anomalies 10. Radix Entomolaris/Paramolaris 11. Severe attrition 12. Traumatized teeth 13. Opposing prosthesis 14. Teeth with sinus tract or abscess 15. Teeth with Periodontal Pockets 16. Patients having any systemic condition eg.Diabetes,Hypertension,Hyperthyroidism,Hypothyroidism etc,influencing the outcome of root canal treatment 17. Patients on any oral medication or having consumed any medication(i.e.anti-inflammatory-analgesic,antibiotic) within 48 hrs of treatment

Design outcomes

Primary

Measure	Time frame
Primary outcome is pain reductionTimepoint: 6,12,24,48,72 hrs, one week	—

Secondary

Measure	Time frame
No occurance of pain and no need for systemic medicationTimepoint: 6,12,24,48,72 hrs and one week	—

Countries

India

Contacts

Public ContactDr Abhilasha Bhawalkar

Dr. D.Y.Patil Dental College and Hospital,Pimpri,Pune

sanjyot.mulay@dpu.edu.in9822036048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026