Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Propofol: Propofol infusion will be used at dose of 4 to 6 ml/kg to maintain anaesthesia through out the cardiopulmonary bypass period in the TIVA group titrated to BIS of less than 60.
Sponsors
SCTIMST fluid research grant
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1.Age from 18 -80 yrs 2.Undergoing CABG or Aortic valve surgery for Aortic stenosis on CPB 3.Consenting for the study
Exclusion criteria
Exclusion criteria: emegency surgery, poor language comprehension, neurologic disorders, allergy to anaesthetic agent,significant carotid artery stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Compare the incidence of early postoperative delirium on post opeative day 1 and 2 in both the groups 2.Compare the cerebral oxygen saturation in both the groupsTimepoint: 1.Compare the incidence of early postoperative delirium in both the groups on post operative days 1 and 2 2.Compare the cerebral oxygen saturation in both the groups baseline before induction,after intubation induction,immediately after going on cardiopulmonary bypass,after aortic cross clamp,at moderate hypothermia(28°c),during rewarming,after cpb and after sternal closure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Intraoperative glycaemic control in both the groups 2.Analyse the Katz 3-5 atherosclerosis in the patients with post op delirium. 3.Analyse incidence of early post-operative cognitive dysfunction in both the groupsTimepoint: 1.Blood glucose baseline at start of case,after going on cpb and immideately after coming off CPB 2.Preoperative TEE KATZ score done after intubation 3.MOCA score for post operative cognitive dysfunction assessment day before surgery and on post operative day 7 | — |
Countries
India
Contacts
Public ContactVarsha A V
SCTIMST
Outcome results
None listed