To study the role of placental vitamin D receptor function alteration in growth restricted foetuses

Placental vitamin D receptor (VDR) target gene expression in idiopathic fatal growth restriction : a case control study

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2021/03/032210

Enrollment

Registered

2021-03-23

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O098- Supervision of other high risk pregnancies

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: All pregnant women more than 28 weeks of gestation with USG diagnosed FGR Spontaneous conception Singleton pregnancy

Exclusion criteria

Exclusion criteria: A. Based oh history and examination Hypertensive disorder of pregnancy, diabetes , chronic hypertension, renal disease , jaundice, epilepsy, multifetal pregnancy , prolonged PROM , SMOKING,ALCOHOL,DRUG abuse, placental abruption B. If any of these investigations are abnormal: OGTT , VDRL, TORCH IgM , Liver function test , Kidney function test, APLA, Fetal anomaly on USG

Design outcomes

Primary

Measure	Time frame
Quantification of placental Vitamin D Receptor target gene expression in Idiopathic Fetal Growth Restriction affected pregnancies and low risk healthy pregnanciesTimepoint: 3 months post pooled sample collection	—

Secondary

Measure	Time frame
1. To correlate maternal vitamin D levels with placental Vitamin D receptor (VDR) target gene expression. 2.To correlate maternal vitamin D levels with the severity of Fetal Growth Restriction 3.To compare placental histopatholological features in Idiopathic Fetal Growth Restriction affected pregnancies with that of low risk pregnanciesTimepoint: July2021	—

Countries

India

Contacts

Public ContactPriya Sharma

University College of Medical Sciences

Richa.agg77@gmail.com9891294244

Outcome results