Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Tablet Melatonin 6 mg, tablet Melatonin 9 mg: Single dose of either tablet Melatonin 6 mg or tablet Melatonin 9 mg will be given orally 2 hours prior to intubation with sips of water t
Sponsors
Reshma B M
DR M SALIM IQBAL
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective surgeries under general anaesthesia 2. Patients belonging to American Society of Anaesthesiologists Physical Status (ASA-PS) 1 and 2
Exclusion criteria
Exclusion criteria: 1. Refusal to consent for study 2. Allergy to melatonin 3. Patients receiving treatment with study drug (melatonin) 4. Anticipated difficult intubation [Modified Mallampati class 3 and 4] 5. More than 2 intubation attempts or intubation time more than 15 seconds 6. Patients with uncontrolled hypertension and diabetes. 7. Patients with severe cardiac, renal or hepatic disease. 8. Pregnancy and lactation. 9. Patients on hypnotics, sedatives, anxiolytics, anti-epileptics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of oral melatonin 6mg compared with 9mg in attenuating the blood pressure (BP) and heart rate (HR) following laryngoscopy and intubation. Timepoint: Baseline, every minute for 5 minutes, 10th and 15th minute after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To assess the level of sedation and anxiety scores before induction of anaesthesia. 2. To assess the side effects like nausea and vomiting in postoperative period 3. To assess hemodynamic response to extubation. Timepoint: 1.To assess the level of sedation and anxiety scores before induction of anaesthesia. 2. To assess the side effects like nausea and vomiting in postoperative period 3. To assess hemodynamic response to extubation. | — |
Countries
India
Contacts
Public ContactReshma B M
Dr B.R. Ambedkar medical college and hospital
Outcome results
None listed