Health Condition 1: I272- Other secondary pulmonary hypertension
Conditions
Interventions
Intervention1: oral triidothyronine: we will give 10 doses of oral triidothyronine to patients starting from POD 1
Control Intervention1: nil: nil
Sponsors
Department of Cardiac Anaesthesia
Eligibility
Inclusion criteria
Inclusion criteria: all children less than 1 year of age undergoing complex cardiac surgeries like arterial switch operation, vsd with PAH, TAPVC repair under CPB
Exclusion criteria
Exclusion criteria: Children who have history of radiation therapy, abnormal baseline thyroid function, thyroid diseases and other endocrine diseases, preoperative thyroid hormone therapy, use of drugs affecting thyroid function, and preoperative use of inotropic drugs for circulatory support, serum level of creatinine >2.0mg/dL downs syndrome mortality during study will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of Triidothyronine therapy on ionotropic requirement (mean ionotropic scores on 3rd postoperative day) in post complex congenital cardiac surgery under cardiopulmonary bypass Timepoint: 3rd postop day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare Thyroid hormone profile. 2.To compare left ventricular function by assessing Left ventricular outflow tract velocity time integral(LVOT VTi), Ejection by echo 3.To assess the effect of T3 on ionotropic requirement in post complex congenital cardiac surgeries in infants. 4.To compare pulmonary function by assessing PaO2/FiO2 Ratio. 5.To compare 24 hours fluid balance. 6.To compare ventilation time, ICU Length of stay. 7. Arrhythmias 8. Sepsisbetween the two groups Timepoint: pod 0,1,2,4,5 | — |
Countries
India
Contacts
Public ContactSujitha Reddy Karri
POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH
Outcome results
None listed