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A CLINICAL TRIAL TO STUDY THE EFFECT OF GRAPE SEED EXTRACT ON MICROORGANISMS CAUSING PYORRHOEA

EFFICACY OF LOCALLY DELIVERED 2% GRAPE SEED EXTRACT ON PORPHYROMONAS GINGIVALIS AND FUSOBACTERIUM NUCLEATUM :A RANDOMIZED PLACEBO CONTROLLED CLINICAL TRIAL - GSE

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032117
Enrollment
60
Registered
2021-03-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: GRAPE SEED EXTRACT CHIP: IT IS A CHIP IMPREGNATED WITH GRAPE SEED EXTRACT. Intervention2: 2% GRAPE SEED EXTRACT CHIP : 2% GRAPE SEED EXTRACT CHIP AT BASELINE. Control Intervention1: PL

Sponsors

Dr SEENA THOMAS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: •Medically fit patients. •Non smokers. •A clinical diagnosis of chronic periodontitis with pocket depth 5-6 mm with evident radiographic horizontal bone loss. •Patients who have not undergone any periodontal therapy in the previous 6 months. •Willingness to provide informed consent. •Willingness to comply with the OHI given.

Exclusion criteria

Exclusion criteria: •Pregnant women and breastfeeding mothers. •Patients taking dietary supplements. •Patients allergic to grape seed extract. •Patients under systemic or topical antibiotic treatments in the past 3 months. •Patients taking any medications that could interact with grape seed extract.

Design outcomes

Primary

MeasureTime frame
CHECKING THE EFFECT OF GRAPE SEED EXTRACT CHIP ON PORPHYROMONAS GINGIVALIS AND FUSOBACTERIUM NUCLEATUMTimepoint: AT THE BASELINE VISIT AND AT 3 MONTHS

Secondary

MeasureTime frame
CHANGES IN PLAQUE INDEX(PI),BLEEDING INDEX(BI) AND PROBING POCKET DEPTH9PPD) WILL BE DOCUMENTEDTimepoint: AT THE BASELINE VISIT AND AT 3 MONTHS

Countries

India

Contacts

Public ContactDr ANUROOPA P

RAJARAJESWARI DENTAL COLLEGE AND HOSPITAL

anuganga04@gmail.com9986719039

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026