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Comparison of intravenous mode of administration of injection of drugs like lidocaine,esmolol and protofol for decreasing the cough and blood pressure and heart rate response while removing the endotracheal tube in patients who underwent off pump coronary artery bypass(heart) surgery

Comparision of intravenous lidocaine,esmolol and propofol for attenuation of sympathomimetic response to extubation in patients undergoing off pump coronary artery bypass(OPCAB) surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032097
Enrollment
150
Registered
2021-03-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I21- Acute myocardial infarction Health Condition 2: I248- Other forms of acute ischemic heart disease

Interventions

Intervention1: esmolol group intravenous: injection esmolol 1mg/kg intravenous route stat dose over a period of one minute used to attenuate sympathomimetic response to extubation in OPCAB patients In

Sponsors

Nanjappa S N PRIMARY INVESTIGATOR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Elective OPCAB surgeries,EF > 50% Airway Mallampati grading 1 and 2

Exclusion criteria

Exclusion criteria: On pump CABG poor lv function (EF less than 50 %) patients on iabp support allergy to study drug unwilling patients difficult airway Morbid obese (BMI > 35 kg/m2) emergency surgery AV Conduction block greater than first degree SBP HR Bronchospasm or bronchial asthma/ COPD pts

Design outcomes

Primary

MeasureTime frame
attenuation of extubation response in OPCAB surgeriesTimepoint: Before administration of study drug,after admistration before extubation,1min,2min,3 min,5min,10minutes—

Secondary

MeasureTime frame
PREVENTION OF MYOCARDIAL ISCHEMIATimepoint: 0 MINUTES TO 2 HOUR—

Countries

India

Contacts

Public Contactnanjappa s n

sri jayadeva institute of cardiovascular sciences mysore

drnanj@gmail.com8970742674

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026