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to study the effects of administration of preoperative clonidine with perioperative dexmedetomidine in attenuation of the hemodynamic responses and blood loss in patients undergoing elective transnasal transsphenoidal resection of pituitary tumors

A comparitive study: preoperative clonidine with perioperative dexmedetomidine in attenuating the hemodynamic responses and blood loss in patients undergoing elective transnasal transsphenoidal resection of pituitary tumors.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032035
Enrollment
60
Registered
2021-03-16
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D3A8- Other benign neuroendocrine tumors

Interventions

Intervention1: Clonidine is administered one eighty minutes Prior to trans nasal trans sphenoid endoscopic surgery for resection of pituitary tumour: Patients being administered tab clonidine 180 minu

Sponsors

akanksha princee
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient fulfilling criteria of American Society of Anaesthesiology (ASA) of Classes I/ II/ III. Patient aged 18-65 years. Patients undergoing elective transnasal transsphenoidal resection of pituitary tumors. Patientâ??s giving consent willingly.

Exclusion criteria

Exclusion criteria: GCS less than 15 Preoperative Heart Rate less than 50 beat/min Pregnant patients Patients who Take any Alpha-Methyldopa,Beta blockers,Calcium Channel blockers CAD,EF >40%,pre-existing arrythmias and heartblock. Patients with prexisting psychiatric or neurological illnesses Emergency pitutary surgery incase of bleed Renal insuffuciency Allergy in dexmedethomidine and opioid Morbid Obesity Denied consent

Design outcomes

Primary

MeasureTime frame
To compare preoperative clonidine with perioperative dexmedetomidine in attenuating the hemodynamic responses and blood loss in patients undergoing elective transnasal transsphenoidal resection of pituitary tumorsTimepoint: all the demographics along with haemodyanamic variables HR SBP DBP MAP SpO2 notes at baseline, before and after (insertion of nasal pack)intubation,insertion of endoscope then every 10 minutes ,till 5 min prior extubation and at extubation—

Secondary

MeasureTime frame
To obtain smooth emergence to facilitate prompt neurological assessment To compare total dose of Propofol given in both the groups.Timepoint: blood loss at the end of surgery in millilitres and total intraoperative propofol used are noted and any other adverse events incurred intaroperatively are recorded—

Countries

India

Contacts

Public ContactDrDurga Jethava

Mahatma Gandhi Medical College And Hospital

drrssisodia@gmail.com9214035870

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026