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Benzydamine in reducing incidence and severity of post-operative sore throat, hoarseness of voice and cough

A comparative study between Benzydamine Hydrochloride (0.15%) spray and Lidocaine Hydrochloride(10%) spray on endotracheal tube cuff in reducing pot-operative sore throat, hoarseness of voice and cough a one year randomised clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/032029
Enrollment
60
Registered
2021-03-16
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Benzydamine Hydrochloride: Topical non-steroidal anti-inflammatory drug with local anaesthetic properties administered once over the cuff of the endotracheal tube with duration for 2 ho

Sponsors

KLE university Jawaharlal Nehru medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients who provide consent 2 American Society of Anaesthesiologists Grade 1 and 2 3 Modified Mallampati Grade 1 and 2 4 Duration of surgery between 30 minutes to 120 minutes 5 Patients undergoing elective surgery under general anaesthesia with single lumen oro-tracheal intubation

Exclusion criteria

Exclusion criteria: 1 Patient already with upper respiratory tract infection 2 Patient on steroid therapy 3 History of asthma, COPD 4 Difficult airway intubation 5 Awake intubation 6 Retrograde intubation technique

Design outcomes

Primary

MeasureTime frame
drug benzydamine efficacy in reducing incidence and severity of post-operative sore throat, hoarseness of voice and cough after endotacheal intubation.Timepoint: at 0 hour, 1st hour, 6th hour and 24 hours post extubation—

Secondary

MeasureTime frame
To note down any post-operative complications such as laryngospasm, hypotension, hypertension, arrythmias etcTimepoint: AT 0hour, 1st hour, 6th hour, 24 HOURS POST EXTUBATION—

Countries

India

Contacts

Public ContactVinayak Nayak K

KLE UNIVERSITY JNMC BELAGAVI

mcpatil52@gmail.com9743110637

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026