Health Condition 1: Z991- Dependence on respirator
Conditions
Interventions
Intervention1: Dexmedetomidine: Children in dexmedetomidine group will receive intravenous dexmedetomidine infusion as primary sedation starting at 0.5 mcg/kg/hr, without a loading dose. Dose will be
Sponsors
Dr Mrinmayee Deshmukh
Eligibility
Inclusion criteria
Inclusion criteria: All children aged 1 month to less than 18 years of age admitted to Pediatric Intensive Care Unit: who are mechanically ventilated using an endotracheal tube and requiring continuous sedation and intubation for at least next 24 hours (as anticipated by the treating team).
Exclusion criteria
Exclusion criteria: Neurologic injury or pathology/ chronic Central nervous system insult leading to prolonged or permanent weakness, Acute brain injury resulting in altered consciousness or cognitive dysfunction, Requirement of continuous Neuro-muscular blockade, Refractory shock, Bradycardia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of children achieving target sedation scores in State Behavioural Scale score range ( minus 1 to plus 1) for both groups in first 48 hours.Timepoint: Percentage of children achieving target sedation scores in State Behavioural Scale score range ( minus 1 to plus 1) for both groups in first 48 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare cumulative doses of sedative agents and opioids in the two groups.Timepoint: Up to end point of study;To compare drug withdrawal and adverse effects (hypotension, bradycardia, delirium) among the two groups.Timepoint: Withdrawal will be assessed upto 72 hours of start of assessment using Withdrawal Assessment Tool 1. other adverse effects shall be assessed upto end point of study;To compare Pediatric intensive care unit and hospital length of stay among the two groups.Timepoint: Up to hospital stay of patient;To compare the outcome between the two groups.Timepoint: Up to hospital stay of patient;To compare the time to extubation among two groups.Timepoint: Up to Pediatric Intensive Care Unit stay of patient. | — |
Countries
India
Contacts
Public ContactDr Mrinmayee Deshmukh
Lady Hardinge Medical College
Outcome results
None listed