Health Condition 1: N19- Unspecified kidney failure
Conditions
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Presence of cirrhosis of any etiology
Exclusion criteria
Exclusion criteria: 1. Dialysis dependency or having received dialysis in preceding 3 months 2. Active malignancy or treatment for malignancy in last two years 3. Voiding dysfunction or problems 4. Urinary incontinence 5. Pregnancy 6. Allergy to iohexol or iodinated contrast media 7. Amputation of any limb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure glomerular filtration rate (reference GFR) in Indian patients with cirrhosis (in derivation cohort andsubsequently in validation cohort). Derive prediction equation for estimation of glomerular filtration rate (eGFR) against reference GFRas measured by multiple sample plasma and urine iohexol clearance in derivation cohort.Timepoint: at baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare accuracy of MDRD 4 and MDRD 6 equations with reference GFR in derivation and validation cohorts. Percentage of subjects in validation cohort with eGFR (by newly derived prediction equation in derivation cohort) within 30% of measured GFR by multiple sample plasma and urine iohexol clearanceTimepoint: DAY 1 | — |
Countries
India
Contacts
Public ContactDr Smita Divyaveer
POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH,
Outcome results
None listed