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A clinical study to compare the use of bone derived from animal versus bone derived from human, using a membrane made from patients blood, for the treatment of bone defect in lower back teeth

Comparative evaluation of naturally derived bovine hydroxyapatite (Cerabone) combined with platelet-rich fibrin versus allograft with platelet-rich fibrin in the treatment of grade II mandibular furcation defects. A Randomized Clinical Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/031953
Enrollment
20
Registered
2021-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Xenograft: Naturally derived bovine hydroxyapetite bone graft. Control Intervention1: Allograft: Demineralized Freeze Dried Bone

Sponsors

Suhina Mitra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients who agree to participate in the study by signing the informed consent. 2) Age >= 18 years irrespective of gender 3) Mandibular molars with grade II furcation defects (Hamp et all 1975) Non-exposed furcation lesion- Class II (Pilloni et al 2018) 4) Vertical clinical attachment loss of >= 4mm after initial therapy 5) Full mouth plaque index score 6) Adequate gingival biotype of >= 1mm

Exclusion criteria

Exclusion criteria: 1) Patients with systemically compromised health and contraindicated for periodontal surgery. 2) Periodontal surgical treatment during the previous 24 months in the involved site. 3) Pregnant or lactating mothers. 4) Patients with tobacco consumption habit of any type 5) Third molars with furcation involvement 6) Restorations and superficial caries in the area to be treated. 7) Immunocompromised individuals 8) Patients undergoing orthodontic involvement

Design outcomes

Primary

MeasureTime frame
The aim of the study is to clinically and radiographically compare the treatment outcomes of naturally derived bovine hydroxyapatite (Cerabone) combined with platelet-rich fibrin versus allograft with platelet-rich fibrin in the treatment of grade II mandibular furcation defects.Timepoint: baseline and 6 months—

Secondary

MeasureTime frame
â?¢ To evaluate the clinical outcome of naturally derived bovine hydroxyapatite (Cerabone) combined with platelet-rich fibrin in grade II mandibular furcation defects.Timepoint: Baseline and 6 months post treatment—

Countries

India

Contacts

Public ContactSuhina Mitra

Manipal College of Dental Sciences - Mangalore

deepa.gkamath@manipal.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026