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Comparing the efficacy of Propofol and Dexmedetomidine in controlling painful stress while skull pin insertion, used for position of head during brain tumor surgeries. propofol and dexmedetomidine are drugs used for starting of anaesthesia and maintaining blood pressure,heart rate during surgery"

Comparative Study Between Propofol Infusion And Dexmedetomidine Infusion On Hemodynamic Response And Blood Glucose Levels During Scalp Pin Insertion In Intracranial Tumor Surgeriesâ??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/031948
Enrollment
80
Registered
2021-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D332- Benign neoplasm of brain, unspecified

Interventions

Intervention1: propofol infusion: intravenous infusion at 150 mcg/kg/min started after endotracheal intubation and stopped soon after skull pin insertion Control Intervention1: Dexmedetomidine infusio

Sponsors

Dr Ramya Varda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients who have given consent for the study 2.Patients posted for elective intracranial tumor surgeries 3. ASA Grade 1 & 2 4.Age 18-60 years

Exclusion criteria

Exclusion criteria: 1. Known history of allergies to Propofol, Dexmedetomidine 2. Baseline Heart rate 3. Known cases of heart block 4. Known cases of Coronary Artery Disease 5. Known case of Diabetes mellitus type 2, hypertension, pregnancy 6. Previous craniotomy incision 7. Emergency Operations 8. ASA Grade 3 and 4 9. Patients on steroids, psychoactive medications, alpha 2 agonists or antagonists, beta blockers 10. Patients with any known endocrine disorders 11. Patients with hepatic impairment 12. Difficult intubation or repeated attempts of intubation

Design outcomes

Primary

MeasureTime frame
compare the effects of propofol infusion and dexmedetomidine infusion on blood glucose levelsTimepoint: baseline (pre operative) 0 min (just before pin insertion) 20 min after pin insertion 40 min after pin insertion—

Secondary

MeasureTime frame
The hemodynamic response after propofol infusion and dexmedetomidine infusionTimepoint: Baseline (pre operative) 0 min (just before pin insertion) 1 in after pin insertion 3 min after pin insertion 5 min after pin insertion—

Countries

India

Contacts

Public ContactProf Swastika Swaro

Institute Of Medical Sciences And SUM Hospital

drswastika81@yahoo.com9861628628

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026