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comparative evaluation of bone graft with a blood product and bone graft alone in treatment of bone defects created by gum diseases.

â??Comparative Clinical and Radiographic Evaluation of the Efficacy of Autologous Injectable Platelet-Rich Fibrin (iPRF) with Demineralized freeze dried bone allograft (DFDBA) and Normal Saline with Demineralized freeze dried bone allograft (DFDBA) used in the Treatment Of Intrabony Defects in Chronic Periodontitis Patients â??A Randomized Clinical Trialâ??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/031929
Enrollment
40
Registered
2021-03-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K05- Gingivitis and periodontal diseases Health Condition 2: R688- Other general symptoms and signs

Interventions

Intervention1: Demineralized freeze dried bone allograft with normal saline: Open flap debridement, followed by placement of Normal saline with demineralized freeze-dried bone allograft (DFDBA) in the

Sponsors

DR BHALCHANDRA THORAT
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age group between 20-60years Diagnosis with chronic periodontitis Patients in good systemic health with no contraindication to periodontal surgery Patients having Intrabony defects with pocket depths of 5mm or more,intrabony defect of 3mm with radiographic evidence of vertical / angular bone loss in the affected sites. Involved teeth to be vital and with no endodontic lesion.

Exclusion criteria

Exclusion criteria: One â?? wall osseous defects. Patients suffering from any systemic diseases or with compromised immune system. Patients who had received any type of periodontal therapy for the past 6 months Patients taking any immuno-suppressive drugs like corticosteroids. Patients with a known history of allergy to doxycycline or Chlorhexidine or any other medicine are used in the study. Patients showing unacceptable oral hygiene compliance during /after the phase I therapy. Patients taking any drug known to cause gingival enlargement. Pregnant and/or lactating mothers. Patients who were smokers or had tobacco in any other form. Endodontically treated teeth. Patient on anticoagulant therapy Patient with bleeding disorders.

Design outcomes

Primary

MeasureTime frame
Plaque index(SILNESS & LOE 1964) Gingival index(LOE & SILNESS 1963) Probing pocket depth(PPD) Clinical attachment Level(CAL)Timepoint: baseline 1 month 3months and 6 months postoperatively.—

Secondary

MeasureTime frame
Radiographic bone fill will be evaluated using intraoral periapical radiographs of the surgical site.Timepoint: Radiographs will be taken immediatly post surgery and at six month post surgery—

Countries

India

Contacts

Public ContactDR MALA DIXIT BABURAJ

Nair hospital dental college

maladixit25@gmail.com9223340938

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026