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Effect of fentanyl on propofol

An entropy based observational study to determine the effect of varying time intervals between fentanyl and propofol administration on propofol requirement for induction of anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/03/031878
Enrollment
84
Registered
2021-03-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

None listed

Sponsors

kasturba medical college mangalore
Lead Sponsor
chetan s
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age group between 18 years to 65 years, undergoing elective surgery under general anaesthesia under American Society of Anaesthesiologists physical status I-II.

Exclusion criteria

Exclusion criteria: 1. Patient refusing consent to participate in the study will not be included. 2. Patients with history of allergy to propofol or fentanyl. 3. Patients with BMI >30kg/m2. 4. Anticipated difficult airway. 5. Patients with respiratory, cerebrovascular, renal and cardiovascular diseases including hypertension. 6. Patients receiving any drugs likely to affect requirement of propofol and/or haemodynamic parameters. 7. Patients with history of alcohol or drug use, dehydration and emergency surgery are excluded from the study.

Design outcomes

Primary

MeasureTime frame
The primary outcome measures will be the total dose of propofol and the dose of propofol required in milligram per kg body weight for induction of anaesthesia. Timepoint: 0 , 3 min ,6 min according to the group

Secondary

MeasureTime frame
Secondary outcome measures will be entropy values, SPO2, Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure of the groups.Timepoint: entropy values upto 10mins other secondary outcomes till 30 min

Countries

India

Contacts

Public ContactCHETAN S

KASTURBA MEDICAL COLLEGE, MANGALORE

sureshyv63@gmail.com9845085108

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026