Health Condition 1: G890- Central pain syndrome
Conditions
Interventions
Intervention1: DULOXETINE: duloxetine 30mg in the night every day and followed up at 2weeks if no response, i.e, decrement in NRS score less than 2 then the dose is doubled and again followed up afte
Sponsors
INSTITUE OF MEDICAL SCIENCES BHU
Eligibility
Inclusion criteria
Inclusion criteria: �Aged 18 years or older �Positive history of hemorrhagic or ischemic stroke with lesion in the unilateral brain region proved by computed tomography or magnetic resonance imaging of the brain �Presence of signs and symptoms in accordance with a decrease in pain and heat sensations in the affected part of the body �Presence of spontaneous or stimulated pain in the affected side, which could be smaller or the same in size as the sensory impairment area, fulfilling the mandatory criteria proposed by Klit et al. �Patients with moderate to severe pain (Numeric Rating Scale (NRS) score of 4 and higher) are included. � Patients who are already on any other drugs for CPSP can be included in the study after providing a washout period of two weeks �Only first episode stroke patients to be taken in the study.
Exclusion criteria
Exclusion criteria: �Not willing to participate in the study �Lack of imaging findings compatible with stroke (like tumors) �Likely peripheral causes of pain (pain due to spasticity, nociceptive, psychogenic causes) �Hypersensitivity to duloxetine �Previous treatment with SNRIs �Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in pain intensity from baseline to 4weeks, as assessed by numeric rating scale(NRS), ranging from 0- no pain to 10- worst imaginable pain during the previous 24hoursTimepoint: baseline, 2weeks, 4weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in average pain severity as measured by short form Mc Gill pain questionnaire (SFMPQ) during the previous 24hours Timepoint: baseline, 2weeks, 4weeks;change in pain disability index (PDI)Timepoint: baseline, 2weeks, 4weeks;patient global impression of change(PGIC)Timepoint: 4 weeks | — |
Countries
India
Contacts
Public ContactDr BANDARI MAHESH
INSTITUTE OF MEDICAL SCIENCES, BANARAS HINDU UNIVERSITY
Outcome results
None listed