Health Condition 1: D519- Vitamin B12 deficiency anemia, unspecified
Conditions
Interventions
Intervention1: Sublingual tablet of methyl cobalamin (1500 mcg): Tablet methyl cobalamin (1500 mcg) given on Day 1,3,5,7,and 9 (5 doses). Tablet methyl cobalamin (1500 mcg) will be given in follow up
Sponsors
Intramural Research Grant University College of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Vitamin B12 deficient (serum cobalamin 84+ (age in years x 0.6) fl OR (2) hypersegmented neutrophils or macrocytes on peripheral smear OR (3) bone marrow examination suggestive of megaloblastic anemia
Exclusion criteria
Exclusion criteria: Children with neurological manifestations of vitamin B12 deficiency,critical illness; proton pump inhibitors usage for >2 weeks; history of recent blood transfusion/ use of hematinics (within 12 weeks); deranged KFT; drugs like 6 MP, methotrexate, carbamazepine, valproate, phenobarbitone, phenytoin; aplastic anemia, malignancy, thalassemia, inborn error of metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in serum cobalamin levelsTimepoint: Day 40 of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Change in Hb, reticulocyte hemoglobin equivalent & reticulocyte count on Day 10 and Day 40 (2) Change in Homocysteine levels on Day 40 of treatment (3) Proportion of children needing rescue therapy with IM vitamin B12 on day 10 and day 40.Timepoint: Day 10, Day 40 | — |
Countries
India
Contacts
Public ContactChahat Saxena
University College of Medical Sciences
Outcome results
None listed