Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Dexmedetomidine: An infusion of 1 mcg/kg dexmedetomidine diluted in normal saline to make it a total volume of 50 ml to be started for 10 mins prior to starting the procedure for awake
Sponsors
IMS and SUM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA grade I and II 2. Patients with difficult intubation
Exclusion criteria
Exclusion criteria: 1. Refusal of patient to participate in the study 2. ASA grade II/ III 3. Any allergy to dexmedetomidine 4. Patients on any of the following: a. Higher degree of A-V block b. Treatment with ACE Inhibitors, digoxin or beta adrenergic antagonist c. Treatment with alpha-2 agonist d. Long term use of benzodiazepine or TCA e. Treat with anticoagulants 5. Bleeding disorders 6. Pregnant and nursing women 7. Morbid obesity 8. Lack of cooperative and effective communication 9. Patients requiring post operative ventilatory support
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Airway obstruction score was evaluated using a 3 degree scale 2. Intubation score was evaluated according to Vocal cord movement 3. Coughing 4. Limb movement 5. Fiberoptic intubation comfort score indicating patient tolerance; It was evaluated using a 5 point score 6. Ramsay sedation score: using 6 points 7. Patient satisfaction score Timepoint: At the time of attempting awake fibre optic intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Haemodynamic variables: a. heart rate b. systolic blood pressure c. diastolic blood pressure 2. Any episode of oxygen desaturation ( less than 90%) or bradycardia (HR less than 60 beats/minute).Timepoint: Haemodynamic variables: 1. Baseline: Before drug administration. 2. With the start of the airway manipulation technique (20 min after drug administration). 3. Immediately after intubation. | — |
Countries
India
Contacts
Public ContactPriyangshu Koushik
IMS and SUM hospital
Outcome results
None listed