Health Condition 1: K519- Ulcerative colitis, unspecified
Conditions
Interventions
Intervention1: Calcitriol capsule with standard treatment: Intervention group 1: 0.25 mcg capsule BD of 1,25 dihydroxy Vitamin D3 + 1000 mg calcium carbonate along for 28 days with standard treatment
Sponsors
Post Graduate Institute of Medical education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Clinically diagnosed case of Ulcerative Colitis Clinical indication for standard colonoscopy/sigmoidoscopy
Exclusion criteria
Exclusion criteria: • Unable to provide informed consent Serious life-threatening co-morbidities Pregnant and breastfeeding women Patients with malignancy, serious life-threatening illnesses, renal or hepatic failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in Mayo score from baseline at 4 weeksTimepoint: 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| i. â?¥ 3 point or â?¥ 30% Reduction in Mayo score from baseline at 4 weeks ii. â?¥ 2 Reduction in partial Mayo score at 2 weeks and 4 weeks. iii. Reduction from baseline in fecal calprotectin at 2 and 4 weeks iv. Reduction from baseline in CRP at 2 and 4 weeks v. Improvement in SIBDQ score at 4 weeks vi. Reduction from baseline in Robarts histopathological index (RHI) at 4 weeks vii. Failure of standard treatment requiring upgradation to steroids Timepoint: 4 weeks | — |
Countries
India
Contacts
Public ContactAnurag Sachan
Post-Graduate Institute of Medical Education And Research
Outcome results
None listed