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L-PRF on acceleration of orthodontic tooth movement

Effects of Autologous Leukocyte-Platelet Rich Fibrin(L-PRF) on the Expression of Interleukin-6(ILâ??6) in Gingival Crevicular Fluid during the Comprehensive Orthodontic Treatment: A Randomized Split Mouth Comparative Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/03/031620
Enrollment
18
Registered
2021-03-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Autologous Leukocyte Platelet Rich Fibrin(L-PRF): After leveling and alignment, on the experimental side, the L-PRF plug will be placed into the extraction socket and the canine retract

Sponsors

Iswariya A
Lead Sponsor
Indian council of medical research
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: -Subjects having Class I bimaxillary dentoalveolar protrusion malocclusion or Class II div 1 malocclusion with normo-divergent growth pattern (FMA 20Ë?- 28Ë?), minimum crowding or spacing in maxillary and mandibular arches who require either all 1st premolars or only upper 1st premolars extraction for the correction of their malocclusion. -Presence of full complement of teeth except 3rd molars. -Good oral hygiene (probing depth

Exclusion criteria

Exclusion criteria: -History of complete or incomplete comprehensive orthodontic treatment. -Subject who fails to maintain good oral hygiene all through the orthodontic treatment. -Subjects with pregnancy. -Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism. -Subjects on long term medications like NSAIDâ??S or steroids. -Lack of manual dexterity. -Any medications for systemic illness. -History of recent bacterial or viral infection. -Known blood disorders like thrombocytopenia, leukopenia etc.

Design outcomes

Primary

MeasureTime frame
Increase in the expression of interleukin 6 on the experimental side. Increase in the rate of maxillary canine retraction on the experimental side. Timepoint: T0(before L-PRF placement) T1(1 week after L-PRF placement) T2(2week after L-PRF placement) T3(4week after L-PRF placement) T4(8week after L-PRF placement)—

Secondary

MeasureTime frame
correlation between the concentration of IL-6 in GCF with the rate of canine retraction.Timepoint: T0(before L-PRF placement) T1(1 week after L-PRF placement) T2(2week after L-PRF placement) T3(4week after L-PRF placement) T4(8week after L-PRF placement)—

Countries

India

Contacts

Public ContactIswariya A

AIIMS Bhubaneswar

drashokkjena@gmail.com9438884077

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026