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Comparative study of two types of steroids for severe COVID disease

A retrospective comparative study of methylprednisolone versus dexamethasone in patients with severe COVID disease admitted to intensive care unit

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/03/031614
Enrollment
200
Registered
2021-03-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

None listed

Sponsors

VMMC AND Safdarjung HospitalDelhi
Lead Sponsor
COVID ICU
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: All RT-PCR confirmed COVID 19 positive patients severe COVID-19 disease, who have received steroid therapy (methylprednisolone or dexamethasone)

Exclusion criteria

Exclusion criteria: 1. Patients on chronic steroid therapy 2. Patients having Cushing syndrome 3. Patients on chemotherapy or immunosuppressive drugs 4. Post-operative patients

Design outcomes

Primary

MeasureTime frame
1. Oxygenation ratio (PaO2/FiO2 ratio) 2. Level of biomarkers(IL-1,IL-6,ferritin,TNF-a ) 3. Need for mechanical ventilation 4. duration of ICU stay 5. 30 day mortality Timepoint: 30 days—

Secondary

MeasureTime frame
mortalityTimepoint: 30 days—

Countries

India

Contacts

Public ContactAnjali Kochhar

VMMC and Safdarjung Hospital,Delhi

kochharanjali0@gmail.com01126198462

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026