Health Condition 1: H463- Toxic optic neuropathy
Conditions
Interventions
Intervention1: Standard Therapy with Methylprednisolone: Standard Therapy with Methylprednisolone ( IV 1 gm daily for 5 days)
Control Intervention1: Standard Therapy with Placebo: Standard Therapy wit
Sponsors
Indian Council of Medical ResearchICMR
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age more than13 years 2. Patients receiving Ethambutol for treatment of TB ( PULMONARY/ EXTRAPULMONARY){for analysing the community incidence of EtON}. 3. Patients on Ethambutol developing Optic Neuropathy{ For Intervention}
Exclusion criteria
Exclusion criteria: 1. Patients with secondary causes of visual loss 2. Patients with probable medical conditions with contraindication to steroids a. Activeinfection b. Sepsis c. Uncontrolled Diabetes Mellitus, Hypertension d. Any other contraindication to steroids 3. Pregnant or lactating women 4. Patients not consenting for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in the visual functionsTimepoint: Patients will be assessed after two weeks of pulse dose steroids traetment and will be followed up after one month and then after every two months | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety of the interventionTimepoint: Immediate side effects will be noted at the time of administration of intravenous methylprednisolone. | — |
Countries
India
Contacts
Public ContactVivek Lal
Post Graduate Institute of medical education and Research (PGIMER)
Outcome results
None listed