To study the combined effects of two drugs on succinylcholine induced muscle pain.

To study the combined effects of preoperative diclofenac and precurarization with atracurium on succinylcholine-induced myalgia in laparscopic surgeries

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031590

Enrollment

Registered

2021-02-26

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis Health Condition 2: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Precurarization and analgesia: Diclofenac 100 mg and injection atracurium 0.05mg /kg IV before induction. Control Intervention1: Placebo: Injection normal saline before induction of g

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I posted for laparoscopic cholecystectomy.

Exclusion criteria

Exclusion criteria: BMI > 30kg/m2 Difficult airway Bleeding diasthesis ASA grade II,III, IV.

Design outcomes

Primary

Measure	Time frame
To study the combined effects of pre-operative dose of diclofenac sodium and pre-curarization with Atracurium i.v on succinylcholine-induced myalgia. Timepoint: From induction to 24 hrs after recovery.	—

Secondary

Measure	Time frame
a) To study the association of fasciculation with postoperative myalgia , b) To study the association of creatinine kinase with succinylcholine- induced myalgia. c) to improve patient comfort. Timepoint: From induction to 24 hours after recovery.	—

Countries

India

Contacts

Public ContactDr Amit kumar Tirkey

Rajendra institute of medical sciences

ekramrims@yahoo.co.in9431101186

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026