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Comparing 3 new combinations of numbing agents for lower back tooth pain.

Determination of anesthetic efficacy of lidocaine alone and with magnesium sulphate, dexamethasone and ketorolac as adjuvants in symptomatic irreversible pulpitis -A randomized, double Blind Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/031577
Enrollment
120
Registered
2021-02-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Local anesthesia with epinephrine plus magnesium sulphate: the subject will be evaluated pre-operatively, then inferior alveolar nerve block will be given and pain scores are recorded p

Sponsors

Dr K Shekhar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age range of 18-60 years. 2.Systemically healthy patients (ASA I /II). 3.Patients who required endodontic treatment in lower teeth. 4.Vital teeth with no history of root canal therapy. 5.Patients who had tooth with clinical diagnosis of irreversible pulpitis. 6.Volunteers who suffered from moderate or severe pain. 7.Volunteers who signed a human subject committee approved consent form

Exclusion criteria

Exclusion criteria: 1. Pregnancy or lactation patients. 2.Patients who had taken analgesic or anti-inflammatory drugs within last 8hr. 3.No volunteer under 18 years of age. 4.Any endocrine or infections disease or had any systemic disease that contraindicate endodontic therapy. 5.Active site of pathosis in the area of injection. 6.Moderate to advanced periodontal disease. 7.Non vital teeth (necrosis). 8.Any known sensitivity or other adverse reactions to any of the medication or materials used in the study.

Design outcomes

Primary

MeasureTime frame
the combination of different adjuvants in the study focus on increasing profound pulpal pain relief.Timepoint: The anesthetic solution combination would start its action from 15 minutes of administration and the duration of action would last for 4 hours .

Secondary

MeasureTime frame
the combinations would act on increasing the quality and depth of the local anesthesiaTimepoint: the duration of of local anesthetic action would last for 8 to 12 hours.

Countries

India

Contacts

Public ContactDr K Shekhar

Sri Sai College of Dental Surgery

drshekarmds@gmail.com9985825481

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026