This study is to see the effect of premedication with melatonin and pregabalin Perioperatively in total hip arthroplasty case under spinal anaesthesia

COMPARATIVE STUDY OF PERIOPERATIVE EFFECT OF PREMEDICATION WITH MELATONIN VERSUS PREGABALIN IN TOTAL HIP ARTHROPLASTY UNDER SPINAL ANAESTHESIA

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031574

Enrollment

Registered

2021-02-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M253- Other instability of joint

Interventions

Intervention1: Melatonin tablet: 6 MG Melatonin tablet to be given Orally 2 hours prior to the surgery and we will see the effect for 24 hours post surgery Control Intervention1: Pregabalin: 150 MG Pr

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I and II Duration of surgery 1 to 3 hours

Exclusion criteria

Exclusion criteria: Patient refusal Any contraindication to spinal anaesthesia Acute or chronic neurological disorder ASA III and IV Patient on long term analgesic and opoids History of drug allergy History of taking antidepressant and antipsychotic Inability to communicate with patient

Design outcomes

Secondary

Measure	Time frame
To evaluate effect of study drug on post operative analgesia and consumption of rescue analgesic Effect of study drug on sensory and motor blockade in spinal anaesthesia Effect of study drug on sedation levelTimepoint: To evaluate effect of study drug on post operative analgesia up to 24 hours. Effect of study drug on onset and duration of sensory and motor blockade. Effect of study drug on sedation level up to 24 hour	—

Measure

Time frame

To evaluate effect of study drug on post operative analgesia and consumption of rescue analgesic Effect of study drug on sensory and motor blockade in spinal anaesthesia Effect of study drug on sedation levelTimepoint: To evaluate effect of study drug on post operative analgesia up to 24 hours. Effect of study drug on onset and duration of sensory and motor blockade. Effect of study drug on sedation level up to 24 hour

—

Primary

Measure	Time frame
Effect of study drug on perioperative anxiolysisTimepoint: Effect of study drug after 2 hour	—

Countries

India

Contacts

Public ContactDr Vinod kumar Srivastava

KGMU

vinod123.doctor@gmail.com9415795564

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026