Health Condition 1: I958- Other hypotension
Conditions
Interventions
Intervention1: Inj.Methylene blue: Inj.Methylene blue IV bolus @ 1 mg/kg and continuous IV infusion @ 0.5 mg/kg/h for 4hrs in Septic shock patients
Control Intervention1: Inj.Vasopressin: Inj. Vasopre
Sponsors
Institute of Medical Sciences BHU
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age group between 18-65 years. 2.Patients fulfilling the above criteria for septic shock (Sepsis-3 definition) 3.Patients who required Noradrenaline support of >= 0.2 µg/kg/min to maintain MAP of 65-70 mm Hg.
Exclusion criteria
Exclusion criteria: 1. Patient refusal. 2. Patients who were pregnant 3. Patients with known sensitivity to Methylene Blue. 4. Patient age less than 18 years. 5. Patients with known H/O G6PD disease, valvular heart disease, present or suspected coronary heart disease, and present or suspected acute mesenteric ischemia or vasoplastic diathesis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To Determine whether Methylene Blue will decrease 28-Days mortality, as compared with Vasopressin in patients of septic shock who are on high dose Noradrenaline IV infusion (â?¥ 0.2 µg/kg/min).Timepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| TO Determine beneficial effects of Methylene Blue over Vasopressin in terms of duration of shock and more vasopressor requirements.Timepoint: 24 hours | — |
Countries
India
Contacts
Public ContactDr Shashi Prakash
Institute of medical sciences, BHU
Outcome results
None listed