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To see whether two substances in blood named neutrophil CD64 and Myeloperoxidase in patients with severe infection in the intensive care unit can predict how many of these patients will survive and how many among them will die

The prognostic value of neutrophil CD64 and Myeloperoxidase for predicting mortality in critically ill adult patients with sepsis: A prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/02/031460
Enrollment
80
Registered
2021-02-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A419- Sepsis, unspecified organism

Interventions

None listed

Sponsors

All India Institute of Medical Sciences New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 18-75 year old male and female patients with sepsis (defined as rise in SOFA score of >2 with presumed or proven infection) admitted to the Intensive care unit (ICU) or developed sepsis after admission to the ICU

Exclusion criteria

Exclusion criteria: 1. Patients with advanced malignancy 2. Immunocompromised patients, transplant recipients, patients on immunosuppressants, chemotherapy or radiation therapy 3. Patients with advanced chronic kidney disease (CKD stage 3 or above) and advanced Chronic liver disease (Child-Turcotte-Pugh class B or C) or known heart disease with left ventricular ejection fraction less than 30 percent before admission

Design outcomes

Primary

MeasureTime frame
The association between blood levels of neutrophil CD64(nCD64) and Myeloperoxidase(MPO) with 30 day mortality in critically ill adult patients with sepsisTimepoint: The association between blood levels of neutrophil CD64(nCD64) and Myeloperoxidase(MPO) with 30 day mortality in critically ill adult patients with sepsis—

Secondary

MeasureTime frame
The predictive ability of nCD64, MPO and procalcitonin (PCT) levels in adult sepsis patients with respect to culture positivity from presumed sources of infectionTimepoint: Anytime till 30 days from date of admission;The predictive ability of nCD64, MPO and procalcitonin (PCT) levels in adult sepsis patients with respect to duration of ICU stayTimepoint: Till death, discharge or 30 days from date of admission to ICU;The predictive ability of nCD64, MPO and procalcitonin (PCT) levels in adult sepsis patients with respect to maximum observed SOFA scoreTimepoint: Daily, till 30 days from date of admission to the ICU;The predictive ability of nCD64, MPO and procalcitonin (PCT) levels in adult sepsis patients with respect to mortalityTimepoint: Till death, discharge or 30 days from date of admission to the ICU;The predictive ability of nCD64, MPO and procalcitonin (PCT) levels in adult sepsis patients with respect to number of ventilator free daysTimepoint: Daily, till off ventilation or 30 days from date of admission—

Countries

India

Contacts

Public ContactSayan Nath

All India Institute of Medical Sciences, New Delhi

lokeshkashyap@yahoo.com9873531192

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026