Effect of magnesium sulphate on total amount of muscle relaxant required to conduct deep and moderate neuromuscular block surgeries and the effect of magnesium sulphate on total amount of fentanyl required to releive postoperative pain after these surgeries.

Impact of pretreatment with magnesium sulphate on depth of neuromuscular block and postoperative pain in laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031434

Enrollment

Registered

2021-02-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulphate: Deep neuromuscular blockade with magnesium - Will receive magnesium sulphate 30 mg/kg in 100 ml normal saline over 10 minutes as intravenous infusion before inductio

Eligibility

Inclusion criteria

Inclusion criteria: 1)ASA grade 1,2,3 2)Patients aged between 18 to 60 years 3)BMI 4)Patients scheduled for laproscopic cholecystectomy under General Anaesthesia

Exclusion criteria

Exclusion criteria: 1)Patient refusal to give consent 2)Patients with known hypersensitivity to magnesium and cis Atracurium 3)Pregnant patients 4)Patients with history of abdominal surgery 5)Patients with major organ dysfunction 6)Patients using any hypnotics or analgesic 7)Patients having neuromuscular disease that may interfere with neuromuscular function 8)Patients receiving medications known to influence neuromuscular function(eg. calcium channel blockers, phenytoin and aminoglycosides)

Design outcomes

Primary

Measure	Time frame
To calculate and compare total cisatracurium consumption in deep and moderate neuromuscular blockade groups with and without magnesium sulphateTimepoint: After intubation of patient, at 5 minutes , 10 minutes , 15 minutes , 20 minutes , 25 minutes, 30 minutes , 35 minutes , 40 minutes , 2 hours, 6 hours, 12 hours.	—

Secondary

Measure	Time frame
To calculate Minimum effective analgesic dose of fentanyl in post anaesthesi care unit, mean VAS score at rest, on movement and on wound compressionTimepoint: 2 hr, 6 hr, 12 hr after surgery	—

Countries

India

Contacts

Public ContactDr SEEMA JINDAL

GGS MEDICAL COLLEGE AND HOSPITAL, FARIDKOT.

bajwaanureet74.akb@gmail.com9478358947

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026