Health Condition 1: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
None listed
Sponsors
Sir Ganga Ram hospital
Eligibility
Inclusion criteria
Inclusion criteria: The study population includes patients equal to or more than 18 years of age admitted to the adult intensive careunit with severe ARDS (according to Berlin criteria) who are candidates for prone ventilationtherapy and have no contraindications for the placement of an oesophageal balloon catheter
Exclusion criteria
Exclusion criteria: Contraindications to esophageal balloon placement Esophageal or nasopharyngeal pathology (such as tumors, sinusitis , epistaxis,ulcerations, recent surgery or bleeding varices) , Diverticulitis , Bronchopulmonary fistula ,Solid-organ transplantation , History of difficult intubation or airway management ,Duration of ARDS >=36 h or duration of mechanical ventilation >=96 Contraindications to prone positioning Shock (eg, persistent mean arterial pressure 30 mmHg or cerebral perfusion pressure <60 mmHg, Tracheal surgery or sternotomy within two weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the transpulmonary pressures by esophageal pressure measurement in supine andprone position in patients with severe acute respiratory distress syndromeTimepoint: Three consecutive readings of esophageal pressure, airway pressure and transpulmonary pressurewill be obtained from the ventilator display during 5 second pause of end expiration one hour aftercatheter placement in supine position and two hours after maintaining the prone position. Averageof these three readings will be calculated in both the positions and recorded. | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance and PEEP requirements in supine and prone positionTimepoint: Supine and 2 hours after prone position | — |
Countries
India
Contacts
Public ContactDr Vinod kumar Singh
Sir Ganga Ram hospital
Outcome results
None listed