Effect of ultrasound during acute ischemic stroke

Effect of Continuous 2MHz Transcranial targeted Ultrasound as an adjunct to Tenecteplase thrombolysis in Acute anterior circulation ischemic stroke patients: a open labelled randomized clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/02/031418

Enrollment

Registered

2021-02-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I634- Cerebral infarction due to embolism of cerebral arteries

Interventions

Intervention1: 2 MHZ ultrasound (Trancranial Doppler): Transmission of ultrasound waves using the Transcranial Doppler machine to acute stroke patients Control Intervention1: Control Group: Control Gr

Eligibility

Inclusion criteria

Inclusion criteria: Acute ischemic stroke of anterior circulation Age >18yrs Eligible for Intravenous Thrombolysis

Exclusion criteria

Exclusion criteria: Any contraindication to thrombolysis: (Severe hypertension, Seizure at the onset, severe stroke, recent myocardial infarction, recent major surgery -History of Craniotomy, Burr-hole surgery, recent GI bleed) Posterior circulation stroke

Design outcomes

Primary

Measure	Time frame
To determine if addition of continuous 30 minutes of Transcranial Doppler ultrasound to IV thrombolysis with tenecteplase increases the proportion of individuals who have improvement in NIHSS of at least 4 points at 4 hours in acute ischemic stroke subjects of the anterior circulation in comparison to IV tenecteplase aloneTimepoint: To determine if addition of continuous 30 minutes of Transcranial Doppler ultrasound to IV thrombolysis with tenecteplase increases the proportion of individuals who have improvement in NIHSS of at least 4 points at 4 hours in acute ischemic stroke subjects of the anterior circulation in comparison to IV tenecteplase alone	—

Measure

Time frame

To determine if addition of continuous 30 minutes of Transcranial Doppler ultrasound to IV thrombolysis with tenecteplase increases the proportion of individuals who have improvement in NIHSS of at least 4 points at 4 hours in acute ischemic stroke subjects of the anterior circulation in comparison to IV tenecteplase aloneTimepoint: To determine if addition of continuous 30 minutes of Transcranial Doppler ultrasound to IV thrombolysis with tenecteplase increases the proportion of individuals who have improvement in NIHSS of at least 4 points at 4 hours in acute ischemic stroke subjects of the anterior circulation in comparison to IV tenecteplase alone

—

Secondary

Measure	Time frame
Exploratory analysis of TCD waveforms in treatment group to identify spectral patterns and parameters corresponding to responders (those with improvement in NIHSS by 4 points) and compare with the non-responders Timepoint: Analysis of the TCD waveform pattern during the time of thrombolysis administration in acute ischemic stroke	—

Countries

India

Contacts

Public ContactDr Sunil Narayan

Jawaharlal Institute of Postgraduate Medical Education and Research

sunil.narayan@jipmer.edu.in9443617120

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 9, 2026