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Local Use of Antibiotic Powder during total knee replacement

Effect of intrawound vancomycin in prevention of surgical site infection/periprosthetic joint infection after primary total knee arthroplasty: prospective RCT

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/031310
Enrollment
2000
Registered
2021-02-16
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified Health Condition 2: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Intra-wound Vancomycin Group: Patients in this group will undergo primary total knee replacement and will receive 1. Pre-op standard antibiotic (Single-dose pre-operative Intravenous C

Sponsors

Sunshine Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients undergoing primary total knee arthroplasty for osteoarthritis of the knee joint

Exclusion criteria

Exclusion criteria: Inflammatory arthritis Post-traumatic arthritis Previous knee surgery

Design outcomes

Primary

MeasureTime frame
Acute infection rate: Incidence of Surgical Site Infections (SSI) or Periprosthetic Joint Infection (PJI)Timepoint: Assessment and documentation of surgical site infection (SSI) or Peri-prosthetic Joint Infection (PJI) at 2 weeks, 4 weeks, 3 months, 6 months, 1 year after surgery—

Secondary

MeasureTime frame
Correlation of patient factors with infection ratesTimepoint: 6 months and 1 year;Functional outcome assessed by Oxford Knee Score (OKS)Timepoint: 3 months, 6 months, 1 year;Functional outcomes assessment by Patient reported outcome measure (PROM) by Forgotten Joint Score (FJS)Timepoint: 3 months, 6 months, 1 year;Functional outcomes using WOMAC scoreTimepoint: 3 months, 6 months, 1 year;Long term Infection rateTimepoint: 1 year;Quality of Life Indicator (EQ-5D)Timepoint: 3 months, 6 months, 1 year—

Countries

India

Contacts

Public ContactPraharsha Mulpur

Sunshine Hospitals

praharshamulpur9@gmail.com9652111991

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026