Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications
Conditions
Interventions
None listed
Sponsors
Manipal Academy of Higher Education
Eligibility
Inclusion criteria
Inclusion criteria: Patients who are 18 years to 80 years old, visiting Dept. of Surgery & Dept. of Medicine for the management of infected diabetic foot ulcer
Exclusion criteria
Exclusion criteria: Incomplete case records, Patients who missed a follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improved VDR and CAMP gene expression status (Increased) Improved VDR protein & LL-37 (Cathelicidin) status: (normal or high) Improved serum vitamin D status (Sufficient, Insufficient and Deficient) Timepoint: Time points Two time points: At baseline and after 4 months Vitamin D receptor gene and human Cathelicidin antimicrobial peptide(CAMP) gene expression in infected diabetic foot ulcer patients will be checked using real time PCR (RT-PCR) Peptide (VDR protein & Cathelicidin) as well as vitamin D levels will be estimated using ELISA technique Wound healing will be assessed by measuring the wound linearly and the wound area will be calculated by multiplying the two diameters obtained | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in wound length and diameterTimepoint: Time points Two time points: At baseline and after 4 months Wound healing will be assessed by measuring the wound linearly and the wound area will be calculated by multiplying the two diameters obtained from perpendicular measurements | — |
Countries
India
Contacts
Public ContactMs Ruby Benson
Manipal College of Pharmaceutical Sciences, MAHE, Manipal
Outcome results
None listed