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Evaluation of effectiveness of a lab test in detecting diseases of middle layer of eye

Evaluation of the diagnostic utility of Serum Angiotensin Converting Enzyme in patients with uveitis in a tertiary eye care centre

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/02/031276
Enrollment
95
Registered
2021-02-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H200- Acute and subacute iridocyclitis

Interventions

Intervention1: NIL: Not Applicable Control Intervention1: NIL: Not Applicable

Sponsors

Aravind Eye Hospital Pondicherry
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients attending the uvea clinic who are newly diagnosed with acute uveitis who are willing to undergo the test at the reference laboratory attached to Aravind Eye hospital, Pondicherry Chronic uveitis patients presenting with reactivation of the disease Patients of age 18 years and above

Exclusion criteria

Exclusion criteria: Patients with history of trauma Chronic uveitis patients with inactive disease Patients in the pediatric age groups Immunosuppressed patients Patients who are already on ACE inhibitors oral steroids or immunosuppressants

Design outcomes

Primary

MeasureTime frame
Percentage of raised S.ACE levels (52IU/L) among patients with active uveitis Estimated values of Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value of serum ACE investigation in different etiologies of uveitis including ocular TB and Ocular Sarcoidosis by employing different cut-off values Timepoint: At 1 year

Secondary

MeasureTime frame
Percentage of positive Mantoux test value of more than 10mm and estimated values of Sensitivity, Specificity, Positive Predictive value and Negative Predictive Value of Mantoux test in Ocular TB and Ocular Sarcoidosis Percentage of occurrence of lymphopenia and estimated values of Sensitivity, Specificity, Positive Predictive value and Negative Predictive value of lymphopenia in Ocular TB and Ocular Sarcoidosis Timepoint: At Baseline (Day 0)

Countries

India

Contacts

Public ContactDr S Balamurugan

Aravind Eye Hospital Pondicherry

drbalamuruganms@gmail.com9080518580

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026