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comparing the 2 modes of administering phenylepjerine(in the muscle vs intravenous) for preventing fall in blood pressure in pregnant females getting caesarean section done under spinal anaesthesia

COMPARISON OF PHENYLEPHRINE INFUSION VERSUS INTRAMUSCULAR PHENYLEPHRINE REGIMEN FOR PREVENTION OF HYPOTENSION IN CAESAREAN SECTIONS UNDER SPINAL ANESTHESIA: A DOUBLE BLIND RANDOMIZED CONTROLLED TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/031200
Enrollment
60
Registered
2021-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O748- Other complications of anesthesiaduring labor and delivery Health Condition 2: 1- Obstetrics

Interventions

Intervention1: intramuscular phenylepherine 3 mg: single prophylactic dose of intramuscular phenylephrine 3 mg given in the deltoid muscle of the parturient post spinal block placement to prevent hypo

Sponsors

Department of anaesthesia PGIMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Caesarean Section 2. Singleton pregnancy at term 3. 18 â?? 35 years old 4. Height 150 â?? 180 cm

Exclusion criteria

Exclusion criteria: 1. BMI 34.9 2. Refusal of Consent 3. Multiple Pregnancy 4. Pregnancy induced hypertension/ eclampsia/ peripartum bleeding/women in labour 5. Known cardiac disease or chronic hypertension. 6. Foetal distress or complications 7. Contraindication for spinal anaesthesia

Design outcomes

Primary

MeasureTime frame
To compare the umbilical cord blood base excess(BE) between the two groups. Timepoint: at the time of baby delivery, immediately after cord clamping

Secondary

MeasureTime frame
1. To compare the incidence of maternal hypotension in the two groups. 2. Incidence of bradycardia and reactive hypertension. 3. Intraoperative nausea vomiting. 4. Umbilical cord blood parameters apart from BE. i.e. pH, lactate levels.Timepoint: The first three secondary outcomes will be measured every 5 min(5,10,15,20,25,30,35,40,45,50,55,60 min) till the end of surgery. 4th secondary outcome is at the delivery of baby, immediately after cord claping

Countries

India

Contacts

Public ContactPrerna Varma

PGIMER, CHANDIGARH

prerna.varma@gmail.com7087003391

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026