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Evaluation of clonidine as an adjuvant in spinal anaesthesia

Comparison of hyperbaric bupivacaine alone and combination of hyperbaric bupivacaine with clonidine in cesarean section: A prospective randomized clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/02/031199
Enrollment
60
Registered
2021-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O94- Sequelae of complication of pregnancy, childbirth, and the puerperium

Interventions

Intervention1: Group B will receive hyperbaric bupivacaine 10mg with 30 mcg (0.2 ml) clonidine intrathecally: hyperbaric bupivacaine 10mg with 30 mcg (0.2 ml) clonidine intrathecally Control Interven

Sponsors

Dr Aman Malawat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Pregnant women undergoing Elective lower segment Caesarean section with ASA I and II grades. 2. Planned for elective lower segment caesarean section with a singleton fetus & pregnancy at term 3. Patients with age between 18 years and 40 years 4. Patients with weight range between 40-80 kgs. 5. Patients with height between 150cm â?? 180 cm.

Exclusion criteria

Exclusion criteria: 1. Parturients with maternal cardiac and haematological disease, diabetes, eclampsia, bleeding or coagulation test abnormalities, foetal distress and foetal anomalies. 2. Patients with known sensitivity to clonidine 3. Patients with compromised respiratory status like asthma, renal and 4. Hepatic disorders were excluded. 5. Patients on antihypertensive medication.

Design outcomes

Primary

MeasureTime frame
To assess and compare perioperative haemodynamic changes.Timepoint: baseline—

Secondary

MeasureTime frame
compare the side effects of intrathecal hyperbaric bupivacaine and combination of hyperbaric bupivacaine with clonidineTimepoint: baseline;compare the time taken for rescue analgesia in two groups.Timepoint: baseline;To determine the onset of sensory/motor block and recovery from motor block with intrathecal hyperbaric bupivacaine and combination of hyperbaric bupivacaine with clonidine .Timepoint: baseline;To evaluate the safety of intrathecal hyperbaric bupivacaine and combination of hyperbaric bupivacaine with clonidine in terms of maternal and fetal outcome.Timepoint: baseline—

Countries

India

Contacts

Public ContactDr Durga Jethava

Mahatma Gandhi Medical College and Hospital, Jaipur

dr.a.malawat@gmail.com7737200883

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026