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Evaluation of change in neurocognition with midazolam sedation in regional anesthesia

EVALUATION OF EARLY NEUROCOGNITIVE FUNCTIONS WITH THE USE OF MIDAZOLAM IN PATIENTS UNDERGOING LOWER LIMB ORTHOPAEDIC SURGERY UNDER REGIONAL ANESTHESIA:A PROSPECTIVE OBSERVATIONAL STUDY.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/02/031194
Enrollment
40
Registered
2021-02-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M959- Acquired deformity of musculoskeletal system, unspecified

Interventions

None listed

Sponsors

Department of anesthesia
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age > 40 years. 2.American Society of Anaesthesiologists (ASA) class I and II. 3.Duration of surgery > 1hour 4.Patients undergoing lower limb orthopaedic surgery under regional anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Preoperative cognitive dysfunction [mini- cog score >42]. 2.Patients with known psychiatric illness or on antipsychotic drugs or substance abuse. • Severe hepatic or renal insufficiency • Level of education less than 5 th class schooling. • Any carotid or cerebrovascular disease or brain pathology. • Contraindications to regional anaesthesia • Allergy to any of drug used in the procedure

Design outcomes

Primary

MeasureTime frame
To detect the incidence of early neurocognitive function with the use of midazolam as sedative in patients undergoing lower limb orthopaedic surgery under regional anaesthesiaTimepoint: 3 rd and 7 th pod—

Secondary

MeasureTime frame
Determination of factors associated with neurocognitive change. Timepoint: 3rd and 7 th pod—

Countries

India

Contacts

Public ContactLekha

PGIMER

Hembhagat@rediffmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026